|Application ||WB, E|
|Other Accession||O88994, Q9GKW0, NP_060368.2|
|Calculated MW||38023 Da|
|Antigen Region||304-333 aa|
|Other Names||Mitochondrial amidoxime reducing component 2, mARC2, 1---, Molybdenum cofactor sulfurase C-terminal domain-containing protein 2, MOSC domain-containing protein 2, Moco sulfurase C-terminal domain-containing protein 2, MARC2, MOSC2|
|Target/Specificity||This MOSC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 304-333 amino acids from the C-terminal region of human MOSC2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MOSC2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||As a component of the benzamidoxime prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively.|
|Cellular Location||Mitochondrion outer membrane; Peripheral membrane protein. Peroxisome|
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Provided below are standard protocols that you may find useful for product applications.
Catalytic component of the benzamidoxime prodrug-converting complex, a complex required to reduce N-hydroxylated structures, such as benzamidoxime prodrug. Benzamidoxime is an amidine prodrug produced by N-hydroxylation which is used to enhance bioavailability and increase intestinal absorption. It is then reduced into benzamidine, its active amidine, by the benzamidoxime prodrug-converting complex.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Aberg, K., et al. Biol. Psychiatry 67(3):279-282(2010)
Havemeyer, A., et al. J. Biol. Chem. 281(46):34796-34802(2006)
Anantharaman, V., et al. FEMS Microbiol. Lett. 207(1):55-61(2002)
Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
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