MOSC2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q969Z3 |
Other Accession | O88994, Q9GKW0, NP_060368.2 |
Reactivity | Mouse |
Predicted | Monkey, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 38023 Da |
Antigen Region | 304-333 aa |
Gene ID | 54996 |
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Other Names | Mitochondrial amidoxime reducing component 2, mARC2, 1---, Molybdenum cofactor sulfurase C-terminal domain-containing protein 2, MOSC domain-containing protein 2, Moco sulfurase C-terminal domain-containing protein 2, MARC2, MOSC2 |
Target/Specificity | This MOSC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 304-333 amino acids from the C-terminal region of human MOSC2. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | MOSC2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | MTARC2 (HGNC:26064) |
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Synonyms | MARC2, MOSC2 |
Function | Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles (PubMed:21029045, PubMed:24423752). As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability (PubMed:21029045, PubMed:24423752). May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis (PubMed:21029045). Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction (PubMed:21029045). |
Cellular Location | Mitochondrion outer membrane; Peripheral membrane protein. Peroxisome |
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Provided below are standard protocols that you may find useful for product applications.
Background
Catalytic component of the benzamidoxime prodrug-converting complex, a complex required to reduce N-hydroxylated structures, such as benzamidoxime prodrug. Benzamidoxime is an amidine prodrug produced by N-hydroxylation which is used to enhance bioavailability and increase intestinal absorption. It is then reduced into benzamidine, its active amidine, by the benzamidoxime prodrug-converting complex.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Aberg, K., et al. Biol. Psychiatry 67(3):279-282(2010)
Havemeyer, A., et al. J. Biol. Chem. 281(46):34796-34802(2006)
Anantharaman, V., et al. FEMS Microbiol. Lett. 207(1):55-61(2002)
Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
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