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MOSC2 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - MOSC2 Antibody (C-term) AP13573B
    MOSC2 Antibody (C-term) (Cat. #AP13573b) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the MOSC2 antibody detected the MOSC2 protein (arrow).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q969Z3
Other Accession O88994, Q9GKW0, NP_060368.2
Reactivity Mouse
Predicted Monkey, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 38023 Da
Antigen Region 304-333 aa
Additional Information
Gene ID 54996
Other Names Mitochondrial amidoxime reducing component 2, mARC2, 1---, Molybdenum cofactor sulfurase C-terminal domain-containing protein 2, MOSC domain-containing protein 2, Moco sulfurase C-terminal domain-containing protein 2, MARC2, MOSC2
Target/Specificity This MOSC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 304-333 amino acids from the C-terminal region of human MOSC2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMOSC2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MARC2
Synonyms MOSC2
Function As a component of the benzamidoxime prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively.
Cellular Location Mitochondrion outer membrane; Peripheral membrane protein. Peroxisome
Research Areas
Citations (0)

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Background

Catalytic component of the benzamidoxime prodrug-converting complex, a complex required to reduce N-hydroxylated structures, such as benzamidoxime prodrug. Benzamidoxime is an amidine prodrug produced by N-hydroxylation which is used to enhance bioavailability and increase intestinal absorption. It is then reduced into benzamidine, its active amidine, by the benzamidoxime prodrug-converting complex.

References

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Aberg, K., et al. Biol. Psychiatry 67(3):279-282(2010)
Havemeyer, A., et al. J. Biol. Chem. 281(46):34796-34802(2006)
Anantharaman, V., et al. FEMS Microbiol. Lett. 207(1):55-61(2002)
Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)

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Cat# AP13573B
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Quantity:
(40 western blots)
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