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EMP2 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - EMP2 Antibody (C-term) AP13581b
    EMP2 Antibody (C-term) (Cat. #AP13581b) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the EMP2 antibody detected the EMP2 protein (arrow).
  • IHC-P - EMP2 Antibody (C-term) AP13581b
    EMP2 Antibody (C-term) (Cat. #AP13581b)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of EMP2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P54851
Other Accession NP_001415.1
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 19199 Da
Antigen Region 100-129 aa
Additional Information
Gene ID 2013
Other Names Epithelial membrane protein 2, EMP-2, Protein XMP, EMP2, XMP
Target/Specificity This EMP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 100-129 amino acids from the C-terminal region of human EMP2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsEMP2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EMP2
Synonyms XMP
Function Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation (PubMed:24814193). Facilitates surface trafficking and formation of lipid rafts bearing GPI-anchor proteins (By similarity). Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T-cell mediated cytotoxicity (By similarity). Regulates the plasma membrane expression of the integrin heterodimers ITGA6-ITGB1, ITGA5-ITGB3 and ITGA5-ITGB1 resulting in modulation of cell-matrix adhesion (PubMed:16216233). Also regulates many processes through PTK2. Regulates blood vessel endothelial cell migration and angiogenesis by regulating VEGF protein expression through PTK2 activation (PubMed:23439602). Regulates cell migration and cell contraction through PTK2 and SRC activation (PubMed:21637765, PubMed:22728127). Regulates focal adhesion density, F-actin conformation and cell adhesion capacity through interaction with PTK2 (PubMed:19494199). Positively regulates cell proliferation (PubMed:24814193). Plays a role during cell death and cell blebbing (PubMed:12107182). Promotes angiogenesis and vasculogenesis through induction of VEGFA via a HIF1A-dependent pathway (PubMed:23334331). Also plays a role in embryo implantation by regulating surface trafficking of integrin heterodimer ITGA5-ITGB3 (PubMed:16487956). May play a role in glomerular filtration (By similarity).
Cellular Location Golgi apparatus membrane {ECO:0000250|UniProtKB:O88662}; Multi-pass membrane protein. Cell membrane. Apical cell membrane {ECO:0000250|UniProtKB:O88662}. Membrane raft. Cytoplasm. Nucleus {ECO:0000250|UniProtKB:Q66HH2}. Note=Localizes in cytoplasm, foot processes and cell bodies of podocytes and nucleus of endothelial cells of kidney. Localizes to the apical cell surface in the luminal epithelium and glandular epithelium. Colocalized with ITGB1 and GPI-anchor proteins on plasma membrane {ECO:0000250|UniProtKB:O88662, ECO:0000250|UniProtKB:Q66HH2}
Tissue Location Expressed in ciliary body epithelia, sclera, cornea, and retinal pigment epithelium (at protein level) (PubMed:12710941).
Research Areas
Citations ( 0 )


The function of this protein remains unknown.


Mick, E., et al. J Am Acad Child Adolesc Psychiatry 49(9):898-905(2010)
Fu, M., et al. Clin. Cancer Res. 16(15):3954-3963(2010)
Shimazaki, K., et al. Clin. Cancer Res. 14(22):7367-7377(2008)
Wadehra, M., et al. Reprod. Biol. Endocrinol. 6, 15 (2008) :
Forbes, A., et al. J. Biol. Chem. 282(36):26542-26551(2007)

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$ 295.00
$ 99.00
Cat# AP13581b
(40 western blots)
Availability: In Stock
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