|Application ||WB, E|
|Calculated MW||126149 Da|
|Antigen Region||970-999 aa|
|Other Names||Protocadherin-18, PCDH18, KIAA1562|
|Target/Specificity||This PCDH18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 970-999 amino acids from the C-terminal region of human PCDH18.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PCDH18 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Potential calcium-dependent cell-adhesion protein.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in all tissues, with highest expression in lung and ovary.|
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Provided below are standard protocols that you may find useful for product applications.
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This gene encodes a protein which contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. Although its specific function is undetermined, the cadherin-related neuronal receptor is thought to play a role in the establishment and function of specific cell-cell connections in the brain.
Homayouni, R., et al. Biochem. Biophys. Res. Commun. 289(2):539-547(2001)
Wolverton, T., et al. Genomics 76 (1-3), 66-72 (2001) :
Suzuki, S.T. Exp. Cell Res. 261(1):13-18(2000)
Nollet, F., et al. J. Mol. Biol. 299(3):551-572(2000)
Yagi, T., et al. Genes Dev. 14(10):1169-1180(2000)
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