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SLC30A6 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q6NXT4 |
| Other Accession | Q8BJM5, Q5ZIH3, Q0VC54, Q6GPY1, Q6AZN8, NP_001180442.1, NP_001180443.1, NP_060434.2 |
| Reactivity | Mouse |
| Predicted | Xenopus, Bovine, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 51116 Da |
| Antigen Region | 282-310 aa |
| Gene ID | 55676 |
|---|---|
| Other Names | Zinc transporter 6, ZnT-6, Solute carrier family 30 member 6, SLC30A6, ZNT6 |
| Target/Specificity | This SLC30A6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 282-310 amino acids from the Central region of human SLC30A6. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SLC30A6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SLC30A6 (HGNC:19305) |
|---|---|
| Function | Has probably no intrinsic transporter activity but together with SLC30A5 forms a functional zinc ion:proton antiporter heterodimer, mediating zinc entry into the lumen of organelles along the secretory pathway (PubMed:15994300, PubMed:19366695, PubMed:19759014). As part of that zinc ion:proton antiporter, contributes to zinc ion homeostasis within the early secretory pathway and regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis (PubMed:15994300, PubMed:19759014, PubMed:35525268). |
| Cellular Location | Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in brain; especially in cerebellum, hippocampus, parahippocampal gyrus, superior and middle temporal gyrus Also expressed in B-cells, colon, eye, and lung. Lower expression was present in bone, brain, cervix, ear, heart, kidney, muscle, nerve, pancreas, prostate, skin, stomach, and testis |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A6, permit cellular efflux of zinc (Seve et al., 2004 [PubMed 15154973]).
References
Lyubartseva, G., et al. Brain Pathol. 20(2):343-350(2010)
Fukunaka, A., et al. J. Biol. Chem. 284(45):30798-30806(2009)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Seve, M., et al. BMC Genomics 5 (1), 32 (2004) :
Huang, L., et al. J. Biol. Chem. 277(29):26389-26395(2002)
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