|Application ||WB, E|
|Other Accession||Q8BJM5, Q5ZIH3, Q0VC54, Q6GPY1, Q6AZN8, NP_001180442.1, NP_001180443.1, NP_060434.2|
|Predicted||Xenopus, Bovine, Chicken|
|Calculated MW||51116 Da|
|Antigen Region||282-310 aa|
|Other Names||Zinc transporter 6, ZnT-6, Solute carrier family 30 member 6, SLC30A6, ZNT6|
|Target/Specificity||This SLC30A6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 282-310 amino acids from the Central region of human SLC30A6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SLC30A6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment.|
|Cellular Location||Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Found in vesicles|
|Tissue Location||Expressed in brain; especially in cerebellum, hippocampus, parahippocampal gyrus, superior and middle temporal gyrus. Also expressed in B-cells, colon, eye, and lung. Lower expression was present in bone, brain, cervix, ear, heart, kidney, muscle, nerve, pancreas, prostate, skin, stomach, and testis|
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Provided below are standard protocols that you may find useful for product applications.
Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A6, permit cellular efflux of zinc (Seve et al., 2004 [PubMed 15154973]).
Lyubartseva, G., et al. Brain Pathol. 20(2):343-350(2010)
Fukunaka, A., et al. J. Biol. Chem. 284(45):30798-30806(2009)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Seve, M., et al. BMC Genomics 5 (1), 32 (2004) :
Huang, L., et al. J. Biol. Chem. 277(29):26389-26395(2002)
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