|Application ||WB, E|
|Calculated MW||75483 Da|
|Antigen Region||414-442 aa|
|Other Names||Protein Smaug homolog 2, Smaug 2, hSmaug2, Sterile alpha motif domain-containing protein 4B, SAM domain-containing protein 4B, SAMD4B, SMAUG2|
|Target/Specificity||This SAMD4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 414-442 amino acids from the C-terminal region of human SAMD4B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SAMD4B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has transcriptional repressor activity. Overexpression inhibits the transcriptional activities of AP-1, p53/TP53 and CDKN1A.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Widely expressed in embryonic and adult tissues.|
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Provided below are standard protocols that you may find useful for product applications.
Sterile alpha motif is a widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, it appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine. SAMD4B (Sterile alpha motif domain-containing protein 4B) belongs to the SMAUG family. SAMD4B contains 1 SAM (sterile alpha motif) domain.
Bailey, S.D., et al. Diabetes Care (2010) In press :
Luo, N., et al. BMB Rep 43(5):355-361(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)
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