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TRIM15 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - TRIM15 Antibody (Center) AP13640c
    TRIM15 Antibody (Center) (Cat. #AP13640c) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the TRIM15 antibody detected the TRIM15 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9C019
Other Accession NP_150232.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 52113 Da
Antigen Region 247-276 aa
Additional Information
Gene ID 89870
Other Names Tripartite motif-containing protein 15, RING finger protein 93, Zinc finger protein 178, Zinc finger protein B7, TRIM15, RNF93, ZNF178, ZNFB7
Target/Specificity This TRIM15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 247-276 amino acids from the Central region of human TRIM15.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTRIM15 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TRIM15
Synonyms RNF93, ZNF178, ZNFB7
Function E3 ubiquitin ligase that plays a role in several processes including innate antiviral immnity, cell migration and chemotaxis (PubMed:34142270, PubMed:23077300). Acts as a 'Lys-63'-specific ubiquitin ligase for MAPK1/ERK2 and MAPK3/ERK1, promoting their activation by facilitating their interaction with MAP2K1 and MAP2K2 (PubMed:34497368). Plays also a role in cell migration and chemotaxis by acting as a stable focal adhesion component upon recruitment by multi-adapter protein paxillin/PXN (PubMed:25015296). Functions in the RIGI-mediated interferon induction pathway upstream or at the level of MAVS (PubMed:23077300). Inhibits NF-kappa-B activation by turnover of 'Lys-63'-linked ubiquitination of MAP3K7/TAK1. Mechanistically, prevents TRIM8 cytoplasmic translocation and thus inhibits TRIM8- mediated 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 in the cytoplasm (PubMed:34871740). Plays also an important regulatory effect on the activation of hepatic stellate cells (HSCs).
Cellular Location Cytoplasm. Nucleus Cell junction, focal adhesion Note=Localizes to focal adhesions during the early stage of adhesion biogenesis.
Research Areas
Citations (0)
citation

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Background

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq].

References

McElroy, J.P., et al. Hum. Mol. Genet. 19(15):3080-3088(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009) :
Uchil, P.D., et al. PLoS Pathog. 4 (2), E16 (2008) :
Lamesch, P., et al. Genomics 89(3):307-315(2007)

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$ 182.50
$ 70.00
Cat# AP13640c
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