|Application ||WB, E|
|Calculated MW||48244 Da|
|Antigen Region||279-307 aa|
|Other Names||E3 ubiquitin-protein ligase TRIM31, 632-, Tripartite motif-containing protein 31, TRIM31, C6orf13, RNF|
|Target/Specificity||This TRIM31 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 279-307 amino acids from the C-terminal region of human TRIM31.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TRIM31 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Regulator of Src-induced anchorage independent cell growth (By similarity). May have E3 ubiquitin-protein ligase activity.|
|Cellular Location||Cytoplasm. Mitochondrion. Note=Predominantly expressed in the cytoplasm but a fraction is associated with the mitochondria|
|Tissue Location||Up-regulated in gastric adenocarcinomas.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to both the cytoplasm and the nucleus. Its function has not been identified.
Cirulli, E.T., et al. Eur. J. Hum. Genet. 18(7):815-820(2010)
Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009) :
Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)
Shiina, T., et al. Genetics 173(3):1555-1570(2006)
Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
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