|Application ||WB, IHC-P, E|
|Other Accession||NP_569074.2, NP_569073.1, NP_067629.2, NP_001003827.1|
|Calculated MW||56864 Da|
|Antigen Region||67-96 aa|
|Other Names||Tripartite motif-containing protein 34, Interferon-responsive finger protein 1, RING finger protein 21, TRIM34, IFP1, RNF21|
|Target/Specificity||This TRIM34 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-96 amino acids from the N-terminal region of human TRIM34.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TRIM34 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May function as antiviral protein and may contribute to the defense against retroviral infections.|
|Tissue Location||Isoform 1 is the most abundant form. It is highly expressed in the placenta, spleen, colon and peripheral blood leukocytes.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. Expression of this gene is up-regulated by interferon. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from the upstream TRIM6 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq].
Sawyer, S.L., et al. PLoS Pathog. 3 (12), E197 (2007) :
Li, X., et al. Virology 360(2):419-433(2007)
Zhang, F., et al. Virology 353(2):396-409(2006)
Li, X., et al. J. Virol. 80(13):6198-6206(2006)
Reymond, A., et al. EMBO J. 20(9):2140-2151(2001)
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