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TRIM45 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9H8W5 |
| Other Accession | Q6PFY8, NP_001139107.1, NP_079464.2 |
| Reactivity | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 64359 Da |
| Antigen Region | 389-417 aa |
| Gene ID | 80263 |
|---|---|
| Other Names | Tripartite motif-containing protein 45, RING finger protein 99, TRIM45, RNF99 |
| Target/Specificity | This TRIM45 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 389-417 amino acids from the C-terminal region of human TRIM45. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TRIM45 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRIM45 |
|---|---|
| Synonyms | RNF99 |
| Function | E3 ubiquitin-protein ligase that plays a role in the regulation of inflammatory response (PubMed:36681779). Mechanistically, mediates the 'Lys-48'-linked polyubiquitination of TAB2, a regulatory protein of the kinase TAK1, leading to its degradation via the proteasomal pathway and inhibition of the TLR-mediated inflammatory immune response (PubMed:36681779). May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway. |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Expressed in skeletal muscle, brain, heart and pancreas. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the tripartite motif family. The encoded protein may function as a transcriptional repressor of the mitogen-activated protein kinase pathway. Alternatively spliced transcript variants have been described.
References
Sardiello, M., et al. BMC Evol. Biol. 8, 225 (2008) :
Wang, Y., et al. Biochem. Biophys. Res. Commun. 323(1):9-16(2004)
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