|Application ||WB, E|
|Calculated MW||23046 Da|
|Antigen Region||6-35 aa|
|Other Names||Transmembrane protein 17, TMEM17|
|Target/Specificity||This TMEM17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-35 amino acids from the N-terminal region of human TMEM17.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TMEM17 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).|
|Cellular Location||Cell projection, cilium membrane; Multi-pass membrane protein Note=Localizes to the transition zone of primary cilia|
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Provided below are standard protocols that you may find useful for product applications.
The function of this protein remains unknown.
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Hillier, L.W., et al. Nature 434(7034):724-731(2005)
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