|Application ||WB, E|
|Calculated MW||16140 Da|
|Antigen Region||56-85 aa|
|Other Names||Hemoglobin subunit gamma-1, Gamma-1-globin, Hb F Agamma, Hemoglobin gamma-1 chain, Hemoglobin gamma-A chain, HBG1|
|Target/Specificity||This HBG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-85 amino acids from the Central region of human HBG1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HBG1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.|
|Tissue Location||Red blood cells.|
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Provided below are standard protocols that you may find useful for product applications.
The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.
Zhou, D., et al. Nat. Genet. 42(9):742-744(2010)
Miccio, A., et al. Mol. Cell. Biol. 30(14):3460-3470(2010)
Nuinoon, M., et al. Hum. Genet. (2009) In press :
da Cunha, A.F., et al. Hemoglobin 33(6):439-447(2009)
Hamid, M., et al. Hemoglobin 33(6):428-438(2009)
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