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GRM1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - GRM1 Antibody (C-term) AP13701b
    GRM1 Antibody (C-term) (Cat. #AP13701b) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the GRM1 antibody detected the GRM1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13255
Other Accession NP_001107801.1, NP_000829.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 132357 Da
Antigen Region 1095-1123 aa
Additional Information
Gene ID 2911
Other Names Metabotropic glutamate receptor 1, mGluR1, GRM1, GPRC1A, MGLUR1
Target/Specificity This GRM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1095-1123 amino acids from the C-terminal region of human GRM1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGRM1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GRM1
Synonyms GPRC1A, MGLUR1
Function G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Detected in brain.
Research Areas
Citations (0)

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L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions. [provided by RefSeq].


Jiang, Y., et al. J. Biol. Chem. 285(43):33463-33474(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Gong, P., et al. J. Mol. Neurosci. 42(1):120-126(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Boer, K., et al. Brain Res. 1324, 24-33 (2010) :

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Cat# AP13701b
(40 western blots)
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