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HIST2H2AB Antibody (N-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP13703a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP13703a-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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- Citiations : 0
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HIST2H2AB Antibody (N-term) - Product info | |
| Application | WB
|
| Primary Accession | Q8IUE6 |
| Other Accession | P02263, Q4FZT6, Q8BFU2, Q7L7L0, P35062, Q64523, Q16777, A1A4R1, Q64522, P0CC09, Q6GSS7, Q6FI13, P02262, P22752, P0C0S8, P0C0S9, Q8CGP7, Q99878, Q8CGP6, Q96KK5, Q64598, Q8CGP5, P0C170, P20671, P0C169, Q93077, P04908, NP_778235.1 |
| Reactivity | Human |
| Predicted | Bovine, Chicken, Mouse, Rat |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 13995 Da |
HIST2H2AB Antibody (N-term) - Additional info | |
| Gene ID 317772 | |
| Other Names HIST2H2AB; Histone H2A type 2-B | |
| Target/Specificity This HIST2H2AB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human HIST2H2AB. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions HIST2H2AB Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
HIST2H2AB Antibody (N-term) - Protein Information | |
| Name HIST2H2AB | |
| Function Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling | |
| Cellular Location Nucleus. Chromosome. | |
HIST2H2AB Antibody (N-term) - Related products
HIST2H2AB Antibody (N-term) - Application data
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HIST2H2AB Antibody (N-term) (Cat. #AP13703a) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the HIST2H2AB antibody detected the HIST2H2AB protein (arrow).
HIST2H2AB Antibody (N-term) - Research Areas
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BACKGROUND
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element.
REFERENCES
Bergink, S., et al. Genes Dev. 20(10):1343-1352(2006) Cao, R., et al. Mol. Cell 20(6):845-854(2005) Hagiwara, T., et al. Biochemistry 44(15):5827-5834(2005) Wang, H., et al. Nature 431(7010):873-878(2004) Aihara, H., et al. Genes Dev. 18(8):877-888(2004)
