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HTRA2 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - HTRA2 Antibody (N-term) AP13705a
    HTRA2 Antibody (N-term) (Cat. #AP13705a) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the HTRA2 antibody detected the HTRA2 protein (arrow).
  • WB - HTRA2 Antibody (N-term) AP13705a
    Western blot analysis of HTRA2 (arrow) using rabbit polyclonal HTRA2 Antibody (N-term) (Cat. #AP13705a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the HTRA2 gene.
  • IHC-P - HTRA2 Antibody (N-term) AP13705a
    HTRA2 Antibody (N-term) (Cat. #AP13705a)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of HTRA2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O43464
Other Accession NP_659540.1, NP_037379.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 48841 Da
Antigen Region 73-102 aa
Additional Information
Gene ID 27429
Other Names Serine protease HTRA2, mitochondrial, High temperature requirement protein A2, HtrA2, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI, HTRA2, OMI, PRSS25
Target/Specificity This HTRA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 73-102 amino acids from the N-terminal region of human HTRA2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHTRA2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HTRA2
Synonyms OMI, PRSS25
Function Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.
Cellular Location Mitochondrion intermembrane space. Mitochondrion membrane; Single-pass membrane protein. Note=Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID
Tissue Location Isoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid
Research Areas
Citations (0)

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This gene encodes a serine protease. The protein has been localized in the endoplasmic reticulum and interacts with an alternatively spliced form of mitogen-activated protein kinase 14. The protein has also been localized to the mitochondria with release to the cytosol following apoptotic stimulus. The protein is thought to induce apoptosis by binding the apoptosis inhibitory protein baculoviral IAP repeat-containing 4. Nuclear localization of this protein has also been observed. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined. [provided by RefSeq].


Zurawa-Janicka, D., et al. Expert Opin. Ther. Targets 14(7):665-679(2010)
Kawamoto, Y., et al. Neuropathol. Appl. Neurobiol. 36(4):331-344(2010)
Vande Walle, L., et al. Cell Res. 20(4):421-433(2010)
Hartkamp, J., et al. Mol. Cell 37(2):159-171(2010)
Kruger, R., et al. Neurobiol. Aging (2009) In press :

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$ 295.00
$ 99.00
Cat# AP13705a
(40 western blots)
Availability: In Stock
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