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ICAM3 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - ICAM3 Antibody (Center) AP13708c
    ICAM3 Antibody (Center) (Cat. #AP13708c) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the ICAM3 antibody detected the ICAM3 protein (arrow).
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  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P32942
Other Accession NP_002153.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 59541 Da
Antigen Region 282-310 aa
Additional Information
Gene ID 3385
Other Names Intercellular adhesion molecule 3, ICAM-3, CDw50, ICAM-R, CD50, ICAM3
Target/Specificity This ICAM3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 282-310 amino acids from the Central region of human ICAM3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsICAM3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ICAM3
Function ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha- L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
Cellular Location Membrane; Single-pass type I membrane protein.
Tissue Location Leukocytes.
Research Areas
Citations (0)
citation

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Background

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule.

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Han, S., et al. Hum. Immunol. 71(7):727-730(2010)
Mosbruger, T.L., et al. J. Infect. Dis. 201(9):1371-1380(2010)
Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)
Reuss, R., et al. Mult. Scler. 16(3):366-369(2010)

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$ 182.50
$ 70.00
Cat# AP13708c
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