|Application ||WB, IHC-P, E|
|Other Accession||P21707, P46096, Q60HC0, P47191, P48018, NP_001129278.1, NP_005630.1, NP_001129277.1|
|Predicted||Bovine, Chicken, Monkey, Mouse, Rat|
|Calculated MW||47573 Da|
|Antigen Region||349-377 aa|
|Other Names||Synaptotagmin-1, Synaptotagmin I, SytI, p65, SYT1, SVP65, SYT|
|Target/Specificity||This SYT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 349-377 amino acids from the C-terminal region of human SYT1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SYT1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein. Cytoplasm. Note=Synaptic vesicles and chromaffin granules|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Musch, M.W., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 298 (2), G203-G211 (2010) :
Kathir, K.M., et al. Biochim. Biophys. Acta 1798(2):297-302(2010)
Pattaro, C., et al. BMC Med. Genet. 11, 41 (2010) :
Hamdan, F.F., et al. Ann. Neurol. 65(6):748-753(2009)
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