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CBX3 Antibody (Center)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP13718c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP13718c-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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CBX3 Antibody (Center) - Product info | |
| Application | WB
|
| Primary Accession | Q13185 |
| Other Accession | P23198, NP_009207.2, NP_057671.2 |
| Reactivity | Human |
| Predicted | Mouse |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 20811 Da |
CBX3 Antibody (Center) - Additional info | |
| Gene ID 11335 | |
| Other Names CBX3; Chromobox protein homolog 3; HECH; Heterochromatin protein 1 homolog gamma; Modifier 2 protein | |
| Target/Specificity This CBX3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 90-119 amino acids from the Central region of human CBX3. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions CBX3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
CBX3 Antibody (Center) - Protein Information | |
| Name CBX3 | |
| Function Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins | |
| Cellular Location Nucleus (Potential). Note=Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis (Potential) | |
CBX3 Antibody (Center) - Related products
AP13718c: CBX3 Antibody (Center)
AP8916a: CBX3 Antibody (N-term)
BP8916a: CBX3 Antibody (N-term) Blocking Peptide
CBX3 Antibody (Center) - Application data
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CBX3 Antibody (Center) (Cat. #AP13718c) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the CBX3 antibody detected the CBX3 protein (arrow).
CBX3 Antibody (Center) - Research Areas
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BACKGROUND
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.
REFERENCES
Higo, S., et al. J. Biol. Chem. 285(41):31337-31347(2010) Souza, P.P., et al. BMC Cell Biol. 10, 41 (2009) : Malyavantham, K.S., et al. J. Cell. Biochem. 105(2):391-403(2008) Eguchi, T., et al. Mol. Cell. Biol. 28(7):2391-2413(2008) Mateescu, B., et al. EMBO Rep. 9(3):267-272(2008)
