|Application ||WB, IF, IHC-P, E|
|Other Accession||P42228, NP_003142.1|
|Calculated MW||85941 Da|
|Antigen Region||666-695 aa|
|Other Names||Signal transducer and activator of transcription 4, STAT4|
|Target/Specificity||This STAT4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 666-695 amino acids from the C-terminal region of human STAT4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||STAT4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.|
|Cellular Location||Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells.
Plant, D., et al. Ann. Rheum. Dis. 69(8):1548-1553(2010)
Gestermann, N., et al. Genes Immun. 11(5):432-438(2010)
Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)
Vuong, M.T., et al. PLoS ONE 5 (5), E10559 (2010) :
Glas, J., et al. PLoS ONE 5 (4), E10373 (2010) :
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