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Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, IHC-P, E |
|---|---|
| Primary Accession | Q14765 |
| Other Accession | P42228, NP_003142.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit Ig |
| Calculated MW | 85941 Da |
| Antigen Region | 666-695 aa |
| Gene ID | 6775 |
|---|---|
| Other Names | Signal transducer and activator of transcription 4, STAT4 |
| Target/Specificity | This STAT4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 666-695 amino acids from the C-terminal region of human STAT4. |
| Dilution | WB~~1:1000 IF~~1:10~50 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | STAT4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | STAT4 |
|---|---|
| Function | Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling. |
| Cellular Location | Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells.
References
Plant, D., et al. Ann. Rheum. Dis. 69(8):1548-1553(2010)
Gestermann, N., et al. Genes Immun. 11(5):432-438(2010)
Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)
Vuong, M.T., et al. PLoS ONE 5 (5), E10559 (2010) :
Glas, J., et al. PLoS ONE 5 (4), E10373 (2010) :
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