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FCGR2A Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - FCGR2A Antibody (C-term) AP13724b
    FCGR2A Antibody (C-term) (Cat. #AP13724b) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the FCGR2A antibody detected the FCGR2A protein (arrow).
    detail
  • WB - FCGR2A Antibody (C-term) AP13724b
    Western blot analysis of FCGR2A (arrow) using rabbit polyclonal FCGR2A Antibody (C-term) (Cat. #AP13724b). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the FCGR2A gene.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P12318
Other Accession NP_001129691.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 35001 Da
Antigen Region 256-285 aa
Additional Information
Gene ID 2212
Other Names Low affinity immunoglobulin gamma Fc region receptor II-a, IgG Fc receptor II-a, CDw32, Fc-gamma RII-a, Fc-gamma-RIIa, FcRII-a, CD32, FCGR2A, CD32, FCG2, FCGR2A1, IGFR2
Target/Specificity This FCGR2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 256-285 amino acids from the C-terminal region of human FCGR2A.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFCGR2A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FCGR2A
Synonyms CD32, FCG2, FCGR2A1, IGFR2
Function Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Found on monocytes, neutrophils and eosinophil platelets
Research Areas
Citations (0)
citation

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Background

This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants.

References

Dornan, D., et al. Blood 116(20):4212-4222(2010)
Zhang, C.Y., et al. J. Biol. Chem. 285(44):34250-34258(2010)
Iwasaki, M., et al. Breast Cancer Res. Treat. (2010) In press :
Ho-Pun-Cheung, A., et al. Pharmacogenomics J. (2010) In press :
Sfar, I., et al. Arch Inst Pasteur Tunis 86 (1-4), 51-62 (2009) :

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$ 182.50
$ 70.00
Cat# AP13724b
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