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MMP28 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q9H239 |
| Other Accession | NP_001027449.1, NP_077278.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 58939 Da |
| Antigen Region | 195-223 aa |
| Gene ID | 79148 |
|---|---|
| Other Names | Matrix metalloproteinase-28, MMP-28, 3424-, Epilysin, MMP28, MMP25 |
| Target/Specificity | This MMP28 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-223 amino acids from the Central region of human MMP28. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MMP28 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MMP28 |
|---|---|
| Synonyms | MMP25 |
| Function | Can degrade casein. Could play a role in tissues homeostasis and repair. |
| Cellular Location | Secreted, extracellular space, extracellular matrix |
| Tissue Location | Expressed at high levels in testes and lung. Low levels are detected in kidney, pancreas and skin. Also expressed in fetal lung, brain, skeletal muscle and kidney. Expressed selectively in keratinocytes. Widely expressed in several carcinomas as well. Is up- regulated in response to injury in the skin |
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Provided below are standard protocols that you may find useful for product applications.
Background
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction and tissue remodeling, and disease processes, such as asthma and metastasis. This gene encodes a secreted enzyme that degrades casein. Its expression pattern suggests that it plays a role in tissue homeostasis and in wound repair. Transcript variants encoding different isoforms have been described. [provided by RefSeq].
References
Swingler, T.E., et al. Biochem. J. 427(3):391-400(2010)
Suomela, S., et al. Virchows Arch. 455(6):495-503(2009)
Rodgers, U.R., et al. Matrix Biol. 28(5):263-272(2009)
Heiskanen, T.J., et al. Matrix Biol. 28(2):74-83(2009)
Gruber, H.E., et al. Arthritis Res. Ther. 11 (6), R184 (2009) :
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