|Application ||WB, E|
|Calculated MW||95468 Da|
|Antigen Region||369-398 aa|
|Other Names||Metabotropic glutamate receptor 6, mGluR6, GRM6, GPRC1F, MGLUR6|
|Target/Specificity||This GRM6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 369-398 amino acids from the Central region of human GRM6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GRM6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision.|
|Cellular Location||Cell membrane; Multi-pass membrane protein Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell projection, dendrite. Note=Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane|
|Tissue Location||Detected in melanocytes.|
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Provided below are standard protocols that you may find useful for product applications.
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Fonseca, F., et al. Mol Diagn Ther 14(3):171-178(2010)
Beqollari, D., et al. Mol. Pharmacol. 76(5):992-997(2009)
Need, A.C., et al. Eur. J. Hum. Genet. 17(7):946-957(2009)
Xu, X., et al. Mol. Vis. 15, 2094-2100 (2009) :
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