|Application ||WB, IF, IHC-P, E|
|Calculated MW||26144 Da|
|Antigen Region||173-202 aa|
|Other Names||Mannose-binding protein C, MBP-C, Collectin-1, MBP1, Mannan-binding protein, Mannose-binding lectin, MBL2, COLEC1, MBL|
|Target/Specificity||This MBL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 173-202 amino acids from the C-terminal region of human MBL2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MBL2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA.|
|Tissue Location||Plasma protein produced mainly in the liver.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases.
Auriti, C., et al. Hum. Immunol. 71(11):1084-1088(2010)
Fraser, D.A., et al. J. Immunol. 185(7):3932-3939(2010)
de Wit, E., et al. Mamm. Genome (2010) In press :
Filho, R.M., et al. Viral Immunol. 23(4):449-453(2010)
Hu, Y., et al. Viral Immunol. 23(4):443-447(2010)
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