|Application ||WB, IF, IHC-P, E|
|Calculated MW||15816 Da|
|Antigen Region||118-146 aa|
|Other Names||Interleukin-13, IL-13, IL13, NC30|
|Target/Specificity||This IL13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 118-146 amino acids from the C-terminal region of human IL13.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IL13 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cytokine (PubMed:8096327, PubMed:8097324). Inhibits inflammatory cytokine production (PubMed:8096327). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). May be critical in regulating inflammatory and immune responses (PubMed:8096327, PubMed:8097324). Positively regulates IL31RA expression in macrophages (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq].
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Shi, X., et al. Anat Rec (Hoboken) 293(9):1470-1476(2010)
Beckers, M.M., et al. Eur. J. Intern. Med. 21(4):289-292(2010)
Ho-Pun-Cheung, A., et al. Pharmacogenomics J. (2010) In press :
Zhao, M., et al. J. Biomed. Biotechnol. 2010, 931018 (2010) :
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