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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   IL13 Antibody (C-term)   

IL13 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - IL13 Antibody (C-term) AP13737b
    IL13 Antibody (C-term) (Cat. #AP13737b) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the IL13 antibody detected the IL13 protein (arrow).
  • IF - IL13 Antibody (C-term) AP13737b
    Confocal immunofluorescent analysis of IL13 Antibody (C-term) (Cat#AP13737b) with NCI-H460 cell line followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
  • IHC-P - IL13 Antibody (C-term) AP13737b
    IL13 Antibody (C-term) (AP13737b)immunohistochemistry analysis in formalin fixed and paraffin embedded human lung tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of IL13 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IF, IHC-P, E
Primary Accession P35225
Other Accession NP_002179.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 15816 Da
Antigen Region 118-146 aa
Additional Information
Gene ID 3596
Other Names Interleukin-13, IL-13, IL13, NC30
Target/Specificity This IL13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 118-146 amino acids from the C-terminal region of human IL13.
Dilution WB~~1:1000
IF~~1:10~50
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIL13 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IL13
Synonyms NC30
Function Cytokine (PubMed:8096327, PubMed:8097324). Inhibits inflammatory cytokine production (PubMed:8096327). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). May be critical in regulating inflammatory and immune responses (PubMed:8096327, PubMed:8097324). Positively regulates IL31RA expression in macrophages (By similarity).
Cellular Location Secreted.
Research Areas
Citations (0)

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Background

This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq].

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Shi, X., et al. Anat Rec (Hoboken) 293(9):1470-1476(2010)
Beckers, M.M., et al. Eur. J. Intern. Med. 21(4):289-292(2010)
Ho-Pun-Cheung, A., et al. Pharmacogenomics J. (2010) In press :
Zhao, M., et al. J. Biomed. Biotechnol. 2010, 931018 (2010) :

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$ 295.00
$ 99.00
Cat# AP13737b
Size:
Quantity:
(40 western blots)
Availability: In Stock
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