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CBX1 Antibody (C-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP13741b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP13741b-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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- Citiations : 0
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- Backgrounds
CBX1 Antibody (C-term) - Product info | |
| Application | WB, IHC
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| Primary Accession | P83916 |
| Other Accession | P83917, NP_006798.1, NP_001120700.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 21418 Da |
CBX1 Antibody (C-term) - Additional info | |
| Gene ID 10951 | |
| Other Names CBX1; CBX; Chromobox protein homolog 1; HP1Hsbeta; Heterochromatin protein 1 homolog beta; Heterochromatin protein p25; M31; Modifier 1 protein; p25beta | |
| Target/Specificity This CBX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 155-184 amino acids from the C-terminal region of human CBX1. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions CBX1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
CBX1 Antibody (C-term) - Protein Information | |
| Name CBX1 | |
| Synonyms CBX | |
| Function Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane | |
| Cellular Location Nucleus. Note=Unassociated with chromosomes during mitosis | |
| Tissue Location Expressed in all adult and embryonic tissues. | |
CBX1 Antibody (C-term) - Related products
AP13741b: CBX1 Antibody (C-term)
AP8915c: CBX1 Antibody (C-term)
CBX1 Antibody (C-term) - Application data
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CBX1 Antibody (C-term) (Cat. #AP13741b) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the CBX1 antibody detected the CBX1 protein (arrow).
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CBX1 Antibody (C-term) (AP13741b)immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CBX1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
CBX1 Antibody (C-term) - Research Areas
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BACKGROUND
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq].
REFERENCES
Shiota, M., et al. Endocr. Relat. Cancer 17(2):455-467(2010) Chaturvedi, P., et al. PLoS ONE 5 (5), E10620 (2010) : Souza, P.P., et al. BMC Cell Biol. 10, 41 (2009) : Yahi, H., et al. J. Biol. Chem. 283(35):23692-23700(2008) Olsen, J.V., et al. Cell 127(3):635-648(2006)
