|Application ||WB, E|
|Calculated MW||89923 Da|
|Antigen Region||796-824 aa|
|Other Names||Cadherin-16, Kidney-specific cadherin, Ksp-cadherin, CDH16|
|Target/Specificity||This CDH16 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 796-824 amino acids from the C-terminal region of human CDH16.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CDH16 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Kidney specific.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development.
Thedieck, C., et al. J. Mol. Biol. 378(1):145-153(2008)
Kuehn, A., et al. Am. J. Surg. Pathol. 31(10):1528-1533(2007)
Thedieck, C., et al. Br. J. Cancer 92(11):2010-2017(2005)
Hishikawa, K., et al. Biochem. Biophys. Res. Commun. 328(1):288-291(2005)
Wendeler, M.W., et al. Exp. Cell Res. 294(2):345-355(2004)
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