|Application ||WB, IHC-P, E|
|Calculated MW||62184 Da|
|Antigen Region||82-110 aa|
|Other Names||Dihydropyrimidinase-related protein 1, DRP-1, Collapsin response mediator protein 1, CRMP-1, Unc-33-like phosphoprotein 3, ULIP-3, CRMP1, DPYSL1, ULIP3|
|Target/Specificity||This CRMP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-110 amino acids from the N-terminal region of human CRMP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CRMP1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May participate in cytokinesis.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associated with centrosomes and the mitotic spindle during metaphase|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Ingersoll, R.G., et al. Eur. J. Hum. Genet. 18(6):726-732(2010)
Mukherjee, J., et al. Cancer Res. 69(22):8545-8554(2009)
Mopert, K., et al. Exp. Cell Res. 315(13):2165-2180(2009)
Sandebring, A., et al. PLoS ONE 4 (5), E5701 (2009) :
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