|Application ||WB, IHC-P, E|
|Calculated MW||38999 Da|
|Antigen Region||77-104 aa|
|Other Names||Protein AMBP, Alpha-1-microglobulin, Protein HC, Alpha-1 microglycoprotein, Complex-forming glycoprotein heterogeneous in charge, Inter-alpha-trypsin inhibitor light chain, ITI-LC, Bikunin, EDC1, HI-30, Uronic-acid-rich protein, Trypstatin, AMBP, HCP, ITIL|
|Target/Specificity||This AMBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 77-104 amino acids from the N-terminal region of human AMBP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AMBP Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization.|
|Tissue Location||Expressed by the liver and secreted in plasma. Alpha-1-microglobulin occurs in many physiological fluids including plasma, urine, and cerebrospinal fluid. Inter-alpha- trypsin inhibitor is present in plasma and urine|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a complex glycoprotein secreted in plasma. The precursor is proteolytically processed into distinct functioning proteins: alpha-1-microglobulin, which belongs to the superfamily of lipocalin transport proteins and may play a role in the regulation of inflammatory processes, and bikunin, which is a urinary trypsin inhibitor belonging to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. This gene is located on chromosome 9 in a cluster of lipocalin genes.
Olsson, M.G., et al. Radiat. Res. 174(5):590-600(2010)
Allhorn, M., et al. Blood 99(6):1894-1901(2002)
Amoresano, A., et al. Eur. J. Biochem. 267(7):2105-2112(2000)
Xu, Y., et al. J. Mol. Biol. 276(5):955-966(1998)
Vetr, H., et al. Biol. Chem. Hoppe-Seyler 371(12):1185-1196(1990)
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