|Application ||WB, E|
|Other Accession||P29101, P46097, NP_796376.2, NP_001129976.1|
|Calculated MW||46872 Da|
|Antigen Region||243-272 aa|
|Other Names||Synaptotagmin-2, Synaptotagmin II, SytII, SYT2|
|Target/Specificity||This SYT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 243-272 amino acids from the Central region of human SYT2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SYT2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein. Note=Synaptic vesicles and chromaffin granules.|
|Tissue Location||Expressed in melanocytes (PubMed:23999003).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Synaptotagmins, like SYT2, are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (Hilbush and Morgan, 1994 [PubMed 8058779]).
Young, S.M. Jr., et al. Neuron 63(4):482-496(2009)
Han, C., et al. J. Immunol. 182(5):2986-2996(2009)
Laohavisit, A., et al. Plant Cell 21(2):479-493(2009)
Shi, J., et al. Biochem. Biophys. Res. Commun. 374(2):331-335(2008)
Lee, B.H., et al. Mol. Cell 15(5):741-751(2004)
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