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SYT2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - SYT2 Antibody (Center) AP13771c
    SYT2 Antibody (Center) (Cat. #AP13771c) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the SYT2 antibody detected the SYT2 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q8N9I0
Other Accession P29101, P46097, NP_796376.2, NP_001129976.1
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 46872 Da
Antigen Region 243-272 aa
Additional Information
Gene ID 127833
Other Names Synaptotagmin-2, Synaptotagmin II, SytII, SYT2
Target/Specificity This SYT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 243-272 amino acids from the Central region of human SYT2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSYT2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SYT2 (HGNC:11510)
Function Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).
Cellular Location Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass membrane protein. Note=Synaptic vesicles and chromaffin granules.
Tissue Location Expressed in melanocytes (PubMed:23999003).
Research Areas
Citations (0)

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Background

Synaptotagmins, like SYT2, are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (Hilbush and Morgan, 1994 [PubMed 8058779]).

References

Young, S.M. Jr., et al. Neuron 63(4):482-496(2009)
Han, C., et al. J. Immunol. 182(5):2986-2996(2009)
Laohavisit, A., et al. Plant Cell 21(2):479-493(2009)
Shi, J., et al. Biochem. Biophys. Res. Commun. 374(2):331-335(2008)
Lee, B.H., et al. Mol. Cell 15(5):741-751(2004)

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$ 295.00
$ 99.00
Cat# AP13771c
Size:
Quantity:
(40 western blots)
Availability: In Stock
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