SYT2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q8N9I0 |
Other Accession | P29101, P46097, NP_796376.2, NP_001129976.1 |
Reactivity | Human |
Predicted | Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 46872 Da |
Antigen Region | 243-272 aa |
Gene ID | 127833 |
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Other Names | Synaptotagmin-2, Synaptotagmin II, SytII, SYT2 |
Target/Specificity | This SYT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 243-272 amino acids from the Central region of human SYT2. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SYT2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SYT2 (HGNC:11510) |
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Function | Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). |
Cellular Location | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P29101}; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000250|UniProtKB:P21707}; Single-pass membrane protein {ECO:0000250|UniProtKB:P29101}. Cytoplasm {ECO:0000250|UniProtKB:P29101} |
Tissue Location | Expressed at the neuromuscular junction (PubMed:33659639). Expressed in melanocytes (PubMed:23999003) |
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Provided below are standard protocols that you may find useful for product applications.
Background
Synaptotagmins, like SYT2, are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (Hilbush and Morgan, 1994 [PubMed 8058779]).
References
Young, S.M. Jr., et al. Neuron 63(4):482-496(2009)
Han, C., et al. J. Immunol. 182(5):2986-2996(2009)
Laohavisit, A., et al. Plant Cell 21(2):479-493(2009)
Shi, J., et al. Biochem. Biophys. Res. Commun. 374(2):331-335(2008)
Lee, B.H., et al. Mol. Cell 15(5):741-751(2004)
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