|Application ||WB, IHC-P, E|
|Calculated MW||51718 Da|
|Antigen Region||304-333 aa|
|Other Names||Nuclear receptor subfamily 0 group B member 1, DSS-AHC critical region on the X chromosome protein 1, Nuclear receptor DAX-1, NR0B1, AHC, DAX1|
|Target/Specificity||This NR0B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 304-333 amino acids from the Central region of human NR0B1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NR0B1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity).|
|Cellular Location||Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and nucleus. Homodimers exits in the cytoplasm and in the nucleus|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism.
Li, N., et al. J. Clin. Endocrinol. Metab. 95 (9), E104-E111 (2010) :
Nedumaran, B., et al. J. Biol. Chem. 285(12):9221-9232(2010)
Kinsey, M., et al. Cancer Res. 69(23):9047-9055(2009)
Nagl, F., et al. Am. J. Physiol., Cell Physiol. 297 (5), C1146-C1156 (2009) :
Skinningsrud, B., et al. J. Clin. Endocrinol. Metab. 94(10):4086-4093(2009)
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