|Application ||WB, E|
|Other Accession||P70579, P47743, NP_001120795.1, NP_000836.2|
|Calculated MW||101741 Da|
|Antigen Region||855-884 aa|
|Other Names||Metabotropic glutamate receptor 8, mGluR8, GRM8, GPRC1H, MGLUR8|
|Target/Specificity||This GRM8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 855-884 amino acids from the C-terminal region of human GRM8.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GRM8 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq].
Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Fonseca, F., et al. Mol Diagn Ther 14(3):171-178(2010)
Bozaoglu, K., et al. J. Clin. Endocrinol. Metab. 95(5):2476-2485(2010)
Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010)
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