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G3BP1 Antibody (C-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP13785b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP13785b-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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G3BP1 Antibody (C-term) - Product info | |
| Application | WB, IHC
|
| Primary Accession | Q13283 |
| Other Accession | P97855, Q32LC7, NP_938405.1, NP_005745.1 |
| Reactivity | Human |
| Predicted | Bovine, Mouse |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 52164 Da |
G3BP1 Antibody (C-term) - Additional info | |
| Gene ID 10146 | |
| Other Names G3BP1; G3BP; Ras GTPase-activating protein-binding protein 1; ATP-dependent DNA helicase VIII; GAP SH3 domain-binding protein 1 | |
| Target/Specificity This G3BP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 400-430 amino acids from the C-terminal region of human G3BP1. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions G3BP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
G3BP1 Antibody (C-term) - Protein Information | |
| Name G3BP1 | |
| Synonyms G3BP | |
| Function May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium- dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA | |
| Cellular Location Cytoplasm. Cytoplasm, cytosol. Cell membrane. Nucleus. Note=Cytoplasmic in proliferating cells, can be recruited to the plasma membrane in exponentially growing cells (By similarity). Cytosolic and partially nuclear in resting cells Recruited to stress granules (SGs) upon either arsenite or high temperature treatment. Recruitment to SGs is influenced by HRAS | |
| Tissue Location Ubiquitous. | |
G3BP1 Antibody (C-term) - Related products
AP13785b: G3BP1 Antibody (C-term)
RI12105: G3BP1 predesign siRNA
DC02042: Human G3BP1 cDNA Clone
G3BP1 Antibody (C-term) - Application data
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G3BP1 Antibody (C-term) (Cat. #AP13785b) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the G3BP1 antibody detected the G3BP1 protein (arrow).
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G3BP1 Antibody (C-term) (AP13785b)immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of G3BP1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
G3BP1 Antibody (C-term) - Research Areas
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BACKGROUND
This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
REFERENCES
Gao, X., et al. FEBS Lett. 584(16):3525-3532(2010) Ortega, A.D., et al. J. Cell. Sci. 123 (PT 16), 2685-2696 (2010) : Hinton, S.D., et al. Biochem. J. 427(3):349-357(2010) Shim, J.H., et al. Cancer Prev Res (Phila) 3(5):670-679(2010) Zhang, H.Z., et al. World J. Gastroenterol. 13(30):4126-4130(2007)
