|Application ||WB, E|
|Calculated MW||28248 Da|
|Antigen Region||178-207 aa|
|Other Names||Phosphoinositide-3-kinase-interacting protein 1, Kringle domain-containing protein HGFL, PIK3IP1, HGFL|
|Target/Specificity||This PIK3IP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 178-207 amino acids from the C-terminal region of human PIK3IP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PIK3IP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Negative regulator of hepatic phosphatidylinositol 3- kinase (PI3K) activity.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
PIK3IP1 is a novel protein that shares homology with the p85 subunit of phosphatidylinositol-3-Kinases (PI3Ks). The PI3K is essential for cell proliferation and Survival. The PIK3IP down regulates the activity of the PI3K and induces apoptosis by associating with p85 and p110 to form a complex, using the p85-like domain. However, there is no evidence to suggest that the PIK3IP1 prevents association of p85 and p110 as they associate with very high affinity.
Gao, P., et al. Beijing Da Xue Xue Bao 40(6):572-577(2008)
He, X., et al. Cancer Res. 68(14):5591-5598(2008)
Zhu, Z., et al. Biochem. Biophys. Res. Commun. 358(1):66-72(2007)
Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)
Collins, J.E., et al. Genome Biol. 5 (10), R84 (2004) :
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