|Application ||WB, E|
|Calculated MW||9925 Da|
|Antigen Region||22-50 aa|
|Other Names||Secretoglobin family 1D member 2, Lipophilin-B, SCGB1D2, LIPHB, LPNB|
|Target/Specificity||This SCGB1D2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-50 amino acids from the Central region of human SCGB1D2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SCGB1D2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones.|
|Tissue Location||Highest expression was found in skeletal muscle. Expressed as well in thymus, trachea, kidney, steroid responsive tissues (prostate, testis, uterus, breast and ovary) and salivary gland|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the lipophilin subfamily, part of the uteroglobin superfamily, and is an ortholog of prostatein, the major secretory glycoprotein of the rat ventral prostate gland. Lipophilin gene products are widely expressed in normal tissues, especially in endocrine-responsive organs. Assuming that human lipophilins are the functional counterparts of prostatein, they may be transcriptionally regulated by steroid hormones, with the ability to bind androgens, other steroids and possibly bind and concentrate estramustine, a chemotherapeutic agent widely used for prostate cancer. Although the gene has been reported to be on chromosome 10, this sequence appears to be from a cluster of genes on chromosome 11 that includes mammaglobin 2.
Sjodin, A., et al. Anticancer Res. 28 (3A), 1493-1498 (2008) :
Culleton, J., et al. Int. J. Cancer 120(5):1087-1092(2007)
Sjodin, A., et al. Acta Neuropathol. 109(4):381-386(2005)
Carter, D., et al. Clin. Cancer Res. 9(2):749-754(2003)
Carter, D., et al. Biochemistry 41(21):6714-6722(2002)
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