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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Mouse Acvr1 Antibody (Center)   

Mouse Acvr1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Mouse Acvr1 Antibody (Center) AP13796c
    Mouse Acvr1 Antibody (Center) (Cat. #AP13796c) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the Acvr1 antibody detected the Acvr1 protein (arrow).
  • WB - Mouse Acvr1 Antibody (Center) AP13796c
    Western blot analysis of Acvr1 (arrow) using rabbit polyclonal Mouse Acvr1 Antibody (Center) (Cat. #AP13796c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the Acvr1 gene.
  • WB - Mouse Acvr1 Antibody (Center) AP13796c
    Mouse Acvr1 Antibody (Center) (Cat. #AP13796c) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the Acvr1 antibody detected the Acvr1 protein (arrow).
  • IHC-P - Mouse Acvr1 Antibody (Center) AP13796c
    Mouse Acvr1 Antibody (Center) (AP13796c)immunohistochemistry analysis in formalin fixed and paraffin embedded mouse skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Mouse Acvr1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P37172
Other Accession P80201, Q04771, Q28041, NP_031420.2, NP_001103675.1
Reactivity Human, Mouse
Predicted Bovine, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 57226 Da
Antigen Region 137-166 aa
Additional Information
Gene ID 11477
Other Names Activin receptor type-1, Activin receptor type I, ACTR-I, Serine/threonine-protein kinase receptor R1, SKR1, TGF-B superfamily receptor type I, TSR-I, TSK-7L, Acvr1, Acvrlk2, Tgfb1
Target/Specificity This Mouse Acvr1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 137-166 amino acids from the Central region of mouse Acvr1.
Dilution WB~~1:1000
IHC-P~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Acvr1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Acvr1
Synonyms Acvrlk2, Tgfb1
Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved in left-right pattern formation during embryogenesis.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells
Research Areas
Citations (0)

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Background

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved in left-right pattern formation during embryogenesis.

References

Luo, J., et al. J. Biol. Chem. 285(38):29588-29598(2010)
Song, G.A., et al. J. Biol. Chem. 285(29):22542-22553(2010)
Shimogori, T., et al. Nat. Neurosci. 13(6):767-775(2010)
Suzuki, Y., et al. J. Cell. Sci. 123 (PT 10), 1684-1692 (2010) :
Caronia, G., et al. J. Neurosci. 30(18):6291-6301(2010)

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$ 295.00
$ 99.00
Cat# AP13796c
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Quantity:
(40 western blots)
Availability: In Stock
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