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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Mouse Csnk2a2 Antibody (N-term)   

Mouse Csnk2a2 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Mouse Csnk2a2 Antibody (N-term) AP13804a
    Mouse Csnk2a2 Antibody (N-term) (Cat. #AP13804a) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the Csnk2a2 antibody detected the Csnk2a2 protein (arrow).
  • WB - Mouse Csnk2a2 Antibody (N-term) AP13804a
    Mouse Csnk2a2 Antibody (N-term) (Cat. #AP13804a) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the Csnk2a2 antibody detected the Csnk2a2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O54833
Other Accession P19784, P21869, P20427, NP_034104.1
Reactivity Human, Mouse
Predicted Bovine, Chicken
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 41215 Da
Antigen Region 4-32 aa
Additional Information
Gene ID 13000
Other Names Casein kinase II subunit alpha', CK II alpha', Csnk2a2
Target/Specificity This Mouse Csnk2a2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-32 amino acids from the N-terminal region of mouse Csnk2a2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Csnk2a2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Csnk2a2
Function Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins (By similarity).
Research Areas
Citations (0)

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Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha and alpha' chains contain the catalytic site. Participates in Wnt signaling. CK2 phosphorylates 'Ser-389' of p53/TP53 following UV irradiation (By similarity).


Pastori, V., et al. Biochim. Biophys. Acta 1802 (7-8), 583-592 (2010) :
Cobb, L.J., et al. Mol. Endocrinol. 23(10):1624-1633(2009)
Mueller, T., et al. Hum. Mol. Genet. 18(17):3334-3343(2009)
Maier, B., et al. Genes Dev. 23(6):708-718(2009)
Kang, H., et al. PLoS ONE 4 (8), E6611 (2009) :

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$ 295.00
$ 99.00
Cat# AP13804a
(40 western blots)
Availability: In Stock
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