|Application ||WB, IHC-P, E|
|Calculated MW||83013 Da|
|Antigen Region||310-339 aa|
|Other Names||E3 ubiquitin-protein ligase TRIM36, 632-, RING finger protein 98, Tripartite motif-containing protein 36, Zinc-binding protein Rbcc728, TRIM36, RBCC728, RNF98|
|Target/Specificity||This TRIM36 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 310-339 amino acids from the Central region of human TRIM36.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TRIM36 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome reaction and fertilization (By similarity).|
|Cellular Location||Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasm, cytoskeleton. Note=Found in the acrosomal region of elongated spermatids and mature sperm.|
|Tissue Location||Highly expressed in testis, prostate and brain. Weakly expressed in kidney, lung and heart|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Miyajima, N., et al. Biochem. Biophys. Res. Commun. 381(3):383-387(2009)
Kitamura, K., et al. J. Androl. 26(4):511-518(2005)
Balint, I., et al. Gene 332, 45-50 (2004) :
Reymond, A., et al. EMBO J. 20(9):2140-2151(2001)
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