|Application ||WB, E|
|Other Accession||Q92928, P10536, Q06AU7, Q9D1G1, Q4R8X3, Q2HJH2, NP_112243.1|
|Reactivity||Human, Mouse, Rat|
|Predicted||Bovine, Monkey, Pig|
|Calculated MW||22171 Da|
|Antigen Region||166-194 aa|
|Other Names||Ras-related protein Rab-1B, RAB1B|
|Target/Specificity||This RAB1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-194 amino acids from the C-terminal region of human RAB1B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RAB1B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1B regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum.|
|Cellular Location||Cytoplasm. Membrane; Lipid-anchor; Cytoplasmic side. Preautophagosomal structure membrane; Lipid-anchor; Cytoplasmic side. Note=Targeted by REP1 to membranes of specific subcellular compartments including endoplasmic reticulum, Golgi apparatus, and intermediate vesicles between these two compartments. In the GDP-form, colocalizes with GDI in the cytoplasm (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
Members of the RAB protein family, such as RAB1B, are low molecular mass monomeric GTPases localized on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB1B functions in the early secretory pathway and is essential for vesicle transport between the endoplasmic reticulum (ER) and Golgi (Chen et al., 1997 [PubMed 9030196]; Alvarez et al., 2003 [PubMed 12802079]).[supplied by OMIM].
Yamayoshi, S., et al. J. Virol. 84(9):4816-4820(2010)
Machner, M.P., et al. Science 318(5852):974-977(2007)
Monetta, P., et al. Mol. Biol. Cell 18(7):2400-2410(2007)
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
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