|Application ||WB, E|
|Other Accession||A6P320, Q8CBH7, NP_001096032.1|
|Calculated MW||43878 Da|
|Antigen Region||308-337 aa|
|Other Names||E3 ubiquitin-protein ligase MARCH11, 632-, Membrane-associated RING finger protein 11, Membrane-associated RING-CH protein XI, MARCH-XI, MARCH11|
|Target/Specificity||This MARCH11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-337 amino acids from the C-terminal region of human MARCH11.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MARCH11 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids (By similarity).|
|Cellular Location||Cytoplasmic vesicle membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
MARCH11 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 22.214.171.124). These enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their intracellular transport. March11 appears to have a role in ubiquitin-mediated protein sorting in the trans-Golgi network (TGN)-multivesicular body (MVB) transport pathway (Morokuma et al., 2007 [PubMed 17604280]).
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Morokuma, Y., et al. J. Biol. Chem. 282(34):24806-24815(2007)
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