|Application ||WB, E|
|Other Accession||Q641Z6, Q9WVK4, Q5E9R3, NP_006786.2|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||60627 Da|
|Antigen Region||410-438 aa|
|Other Names||EH domain-containing protein 1, PAST homolog 1, hPAST1, Testilin, EHD1, PAST, PAST1|
|Target/Specificity||This EHD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 410-438 amino acids from the C-terminal region of human EHD1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||EHD1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Plays a role in myoblast fusion. Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth.|
|Cellular Location||Recycling endosome membrane; Peripheral membrane protein. Early endosome membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Preferentially associates with tubular recycling endosomes. Colocalizes with FER1L5 at plasma membrane in myoblasts and myotubes|
|Tissue Location||Highly expressed in testis.|
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Provided below are standard protocols that you may find useful for product applications.
This gene belongs to a highly conserved gene family encoding EPS15 homology (EH) domain-containing proteins. The protein-binding EH domain was first noted in EPS15, a substrate for the epidermal growth factor receptor. The EH domain has been shown to be an important motif in proteins involved in protein-protein interactions and in intracellular sorting. The protein encoded by this gene is thought to play a role in the endocytosis of IGF1 receptors.
Gudmundsson, H., et al. Circ. Res. 107(1):84-95(2010)
Sharma, M., et al. Mol. Biol. Cell 20(24):5181-5194(2009)
Kieken, F., et al. Protein Sci. 18(12):2471-2479(2009)
Jovic, M., et al. Mol. Biol. Cell 20(11):2731-2743(2009)
Fichtman, B., et al. Cell. Mol. Biol. Lett. 13(4):632-648(2008)
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