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BCL2 Antibody (Center)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP13823c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP13823c-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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- Backgrounds
BCL2 Antibody (Center) - Product info | |
| Application | WB
|
| Primary Accession | P10415 |
| Other Accession | P49950, P10417, Q9JJV8, O02718, NP_000624.2 |
| Reactivity | Human, Mouse |
| Predicted | Bovine, Hamster, Rat |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 26266 Da |
BCL2 Antibody (Center) - Additional info | |
| Gene ID 596 | |
| Other Names BCL2; Apoptosis regulator Bcl-2 | |
| Target/Specificity This BCL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-114 amino acids from the Central region of human BCL2. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions BCL2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
BCL2 Antibody (Center) - Protein Information | |
| Name BCL2 | |
| Function Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) | |
| Cellular Location Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein Endoplasmic reticulum membrane; Single-pass membrane protein | |
| Tissue Location Expressed in a variety of tissues. | |
BCL2 Antibody (Center) - Related products
AP1303a: Bcl-2 Antibody (BH3 Domain Specific)
AP13823c: BCL2 Antibody (Center)
BCL2 Antibody (Center) - Application data
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BCL2 Antibody (Center) (Cat. #AP13823c) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the BCL2 antibody detected the BCL2 protein (arrow).
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BCL2 Antibody (Center) (Cat. #AP13823c) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the BCL2 antibody detected the BCL2 protein (arrow).
BCL2 Antibody (Center) - Research Areas
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BACKGROUND
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq].
REFERENCES
Feng, H., et al. Cancer Cell 18(4):353-366(2010) Azad, N., et al. Ann. N. Y. Acad. Sci. 1203, 1-6 (2010) : Dubikov, A.I., et al. Scand. J. Rheumatol. 39(5):368-372(2010) Yu, B., et al. J. Exp. Clin. Cancer Res. 29, 107 (2010) : Trisciuoglio, D., et al. PLoS ONE 5 (7), E11772 (2010) :
