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> home > Products > Antibodies > Biological Process > Cell Differentiation > ARHGAP24 Antibody (C-term)
ARHGAP24 Antibody (C-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AP13826b | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP13826b-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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ARHGAP24 Antibody (C-term) - Product info | |
| Application | WB
|
| Primary Accession | Q8N264 |
| Other Accession | NP_001020787.2, NP_112595.2, NP_001036134.1 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 84258 Da |
ARHGAP24 Antibody (C-term) - Additional info | |
| Gene ID 83478 | |
| Other Names ARHGAP24; FILGAP; Rho GTPase-activating protein 24; Filamin-A-associated RhoGAP; RAC1- and CDC42-specific GTPase-activating protein of 72 kDa; Rho-type GTPase-activating protein 24; RhoGAP of 73 kDa; Sarcoma antigen NY-SAR-88; p73RhoGAP | |
| Target/Specificity This ARHGAP24 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 586-616 amino acids from the C-terminal region of human ARHGAP24. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ARHGAP24 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
ARHGAP24 Antibody (C-term) - Protein Information | |
| Name ARHGAP24 | |
| Synonyms FILGAP | |
| Function Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis | |
| Cellular Location Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction, focal adhesion. Cell projection Note=Localizes to actin stress fibers. In migrating cells, localizes to membrane lamellae and protusions | |
| Tissue Location Isoform 1 is widely expressed with a higher level in kidney. Isoform 2 is mainly expressed in endothelial cells | |
ARHGAP24 Antibody (C-term) - Related products
ARHGAP24 Antibody (C-term) - Application data
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ARHGAP24 Antibody (C-term) (Cat. #AP13826b) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the ARHGAP24 antibody detected the ARHGAP24 protein (arrow).
ARHGAP24 Antibody (C-term) - Research Areas
AntibodiesBiological ProcessCell DifferentiationOrgan DevelopmentSignal TransductionCellular ProcessSystem DevelopmentMulticellular Organismal DevelopmentAnatomical Structure DevelopmentDevelopmental ProcessAnatomical Structure MorphogenesisVasculature DevelopmentBlood Vessel DevelopmentBlood Vessel MorphogenesisAngiogenesisCellular Developmental ProcessAnatomical Structure Formation Involved In MorphogenesisBiological RegulationRegulation Of Biological ProcessMulticellular Organismal ProcessRegulation Of Cellular ProcessCellular CompartmentCytoplasmIntracellular PartIntracellularOrganelleIntracellular OrganelleCell ProjectionPlasma Membrane PartMolecular FunctionProtein BindingPathway PantherAngiogenesisTissueBrianSpleen
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BACKGROUND
ARHGAPs, such as ARHGAP24, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).
REFERENCES
Horinouchi, M., et al. Pediatr Hematol Oncol 27(5):344-354(2010) Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) : Holm, H., et al. Nat. Genet. 42(2):117-122(2010) Pfeufer, A., et al. Nat. Genet. 42(2):153-159(2010) Nakamura, F., et al. PLoS ONE 4 (3), E4928 (2009) :
