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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ARHGAP24 Antibody (C-term)   

ARHGAP24 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - ARHGAP24 Antibody (C-term) AP13826b
    ARHGAP24 Antibody (C-term) (Cat. #AP13826b) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the ARHGAP24 antibody detected the ARHGAP24 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8N264
Other Accession NP_001020787.2, NP_112595.2, NP_001036134.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 84258 Da
Antigen Region 587-616 aa
Additional Information
Gene ID 83478
Other Names Rho GTPase-activating protein 24, Filamin-A-associated RhoGAP, FilGAP, RAC1- and CDC42-specific GTPase-activating protein of 72 kDa, RC-GAP72, Rho-type GTPase-activating protein 24, RhoGAP of 73 kDa, Sarcoma antigen NY-SAR-88, p73RhoGAP, ARHGAP24, FILGAP
Target/Specificity This ARHGAP24 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 587-616 amino acids from the C-terminal region of human ARHGAP24.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsARHGAP24 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms FILGAP
Function Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.
Cellular Location Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction, focal adhesion. Cell projection Note=Localizes to actin stress fibers. In migrating cells, localizes to membrane lamellae and protusions
Tissue Location Isoform 1 is widely expressed with a higher level in kidney. Isoform 2 is mainly expressed in endothelial cells.
Research Areas
Citations (0)

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ARHGAPs, such as ARHGAP24, encode negative regulators of Rho GTPases (see ARHA; MIM 165390), which are implicated in actin remodeling, cell polarity, and cell migration (Katoh and Katoh, 2004 [PubMed 15254788]).


Horinouchi, M., et al. Pediatr Hematol Oncol 27(5):344-354(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Holm, H., et al. Nat. Genet. 42(2):117-122(2010)
Pfeufer, A., et al. Nat. Genet. 42(2):153-159(2010)
Nakamura, F., et al. PLoS ONE 4 (3), E4928 (2009) :

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$ 295.00
$ 99.00
Cat# AP13826b
(40 western blots)
Availability: In Stock
Bulk Size
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