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POF1B Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - POF1B Antibody (Center) AP13828c
    POF1B Antibody (Center) (Cat. #AP13828c) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the POF1B antibody detected the POF1B protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8WVV4
Other Accession NP_079197.3
Reactivity Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 68065 Da
Antigen Region 337-366 aa
Additional Information
Gene ID 79983
Other Names Protein POF1B, Premature ovarian failure protein 1B, POF1B
Target/Specificity This POF1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 337-366 amino acids from the Central region of human POF1B.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPOF1B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name POF1B
Function Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development.
Cellular Location Cell junction, tight junction
Research Areas
Citations (0)

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Premature ovarian failure (POF) is characterized by primary or secondary amenorrhea in women less than 40 years old. Two POF susceptibility regions called 'POF1' and 'POF2' have been identified by breakpoint mapping of X-autosome translocations. POF1 extends from Xq21-qter while POF2 extends from Xq13.3 to Xq21.1. This gene, POF1B, resides in the POF2 region. This gene is expressed at trace levels in mouse prenatal ovary and is barely detectable or absent from adult ovary, in human and in the mouse respectively. This gene's expression is restricted to epithelia with its highest expression in the epidermis, and oro-pharyngeal and gastro-intestinal tracts. The protein encoded by this gene binds non-muscle actin filaments. The role this gene may play in the etiology of premature ovarian failure remains to be determined.


Rizzolio, F., et al. Gene Expr. Patterns 7(4):529-534(2007)
Lacombe, A., et al. Am. J. Hum. Genet. 79(1):113-119(2006)
Bione, S., et al. Hum. Reprod. 19(12):2759-2766(2004)
Bione, S., et al. Semin. Reprod. Med. 18(1):51-57(2000)
Riva, P., et al. Clin. Genet. 50(4):267-269(1996)

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$ 295.00
$ 99.00
Cat# AP13828c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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