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NOSTRIN Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8IVI9 |
| Other Accession | NP_443178.2, NP_001165103.1, NP_001034813.2 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 57660 Da |
| Antigen Region | 296-325 aa |
| Gene ID | 115677 |
|---|---|
| Other Names | Nostrin, BM247 homolog, Nitric oxide synthase traffic inducer, Nitric oxide synthase trafficker, eNOS-trafficking inducer, NOSTRIN |
| Target/Specificity | This NOSTRIN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-325 amino acids from the Central region of human NOSTRIN. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NOSTRIN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NOSTRIN (HGNC:20203) |
|---|---|
| Function | Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane. |
| Cellular Location | [Isoform 1]: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Cytoplasm, cytoskeleton Note=Enriched in selected actin structures (PubMed:16234328, PubMed:16376344) |
| Tissue Location | Expressed at highest levels in heart, kidney, placenta and lung, and at lowest levels in brain, thymus and spleen Present in vascular endothelial cells and placenta. Over-expressed in placenta from women with pre-eclampsia (at protein level) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.
References
Holt, R., et al. Eur. J. Hum. Genet. 18(9):1013-1019(2010)
Maestrini, E., et al. Mol. Psychiatry 15(9):954-968(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Wiesenthal, A., et al. Traffic 10(1):26-34(2009)
Schilling, K., et al. Mol. Biol. Cell 17(9):3870-3880(2006)
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