|Application ||WB, E|
|Other Accession||NP_443178.2, NP_001165103.1, NP_001034813.2|
|Calculated MW||57660 Da|
|Antigen Region||296-325 aa|
|Other Names||Nostrin, BM247 homolog, Nitric oxide synthase traffic inducer, Nitric oxide synthase trafficker, eNOS-trafficking inducer, NOSTRIN|
|Target/Specificity||This NOSTRIN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-325 amino acids from the Central region of human NOSTRIN.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NOSTRIN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.|
|Cellular Location||Isoform 1: Cell membrane; Peripheral membrane protein; Cytoplasmic side Cytoplasmic vesicle. Cytoplasm, cytoskeleton. Note=Enriched in selected actin structures (PubMed:16234328, PubMed:16376344)|
|Tissue Location||Expressed at highest levels in heart, kidney, placenta and lung, and at lowest levels in brain, thymus and spleen. Present in vascular endothelial cells and placenta. Over- expressed in placenta from women with pre-eclampsia (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.
Holt, R., et al. Eur. J. Hum. Genet. 18(9):1013-1019(2010)
Maestrini, E., et al. Mol. Psychiatry 15(9):954-968(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Wiesenthal, A., et al. Traffic 10(1):26-34(2009)
Schilling, K., et al. Mol. Biol. Cell 17(9):3870-3880(2006)
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