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CASP6 Antibody (N-term)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP13835a | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP13835a-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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- Citiations : 0
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- Backgrounds
CASP6 Antibody (N-term) - Product info | |
| Application | WB, IHC
|
| Primary Accession | P55212 |
| Other Accession | NP_116787.1, NP_001217.2 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 33310 Da |
CASP6 Antibody (N-term) - Additional info | |
| Gene ID 839 | |
| Other Names CASP6; MCH2; Caspase-6; Apoptotic protease Mch-2; Caspase-6 subunit p18; Caspase-6 subunit p11 | |
| Target/Specificity This CASP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-45 amino acids from the N-terminal region of human CASP6. | |
| Dilution WB~~1:100~500WB~~1:1000 IHC~~1:10~50 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions CASP6 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. | |
CASP6 Antibody (N-term) - Protein Information | |
| Name CASP6 | |
| Synonyms MCH2 | |
| Function Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death | |
| Cellular Location Cytoplasm. | |
CASP6 Antibody (N-term) - Related products
AP1313b: CASP6 Antibody (C-term)
AP13835a: CASP6 Antibody (N-term)
AP3043a: Phospho-Caspase 6-S257 Antibody
RI10801: CASP6 predesign siRNA
DC00133: Human CASP6 cDNA Clone
LY12240a: CASP6 Over-expression Lysate
BP1313b: CASP6 Antibody (C-term) Blocking Peptide
BP1313d: CASP6 Antibody (S257) Blocking Peptide
BP3043a: Phospho-Caspase 6-S257 Antibody Blocking Peptide
CASP6 Antibody (N-term) - Application data
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Western blot analysis of CASP6 (arrow) using rabbit polyclonal CASP6 Antibody (N-term) (Cat. #AP13835a). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CASP6 gene.
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CASP6 Antibody (N-term) (AP13835a)immunohistochemistry analysis in formalin fixed and paraffin embedded human bladder carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CASP6 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
CASP6 Antibody (N-term) - Research Areas
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BACKGROUND
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq].
REFERENCES
Wurstle, M.L., et al. J. Biol. Chem. 285(43):33209-33218(2010) Lee, S.Y., et al. J Thorac Oncol 5(8):1152-1158(2010) Halawani, D., et al. J. Neurosci. 30(17):6132-6142(2010) Kim, M.S., et al. APMIS 118(4):308-312(2010) Yoo, N.J., et al. Tumori 96(1):138-142(2010)
