|Application ||WB, E|
|Calculated MW||31368 Da|
|Antigen Region||185-213 aa|
|Other Names||DNA repair protein complementing XP-A cells, Xeroderma pigmentosum group A-complementing protein, XPA, XPAC|
|Target/Specificity||This XPA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 185-213 amino acids from the C-terminal region of human XPA.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||XPA Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.|
|Tissue Location||Expressed in various cell lines and in skin fibroblasts.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq].
Palli, D., et al. Mutagenesis 25(6):569-575(2010)
Fan, W., et al. Mol. Cell 39(2):247-258(2010)
Ho-Pun-Cheung, A., et al. Pharmacogenomics J. (2010) In press :
Hsieh, Y.Y., et al. Anticancer Res. 30(6):2203-2208(2010)
Jelonek, K., et al. J. Appl. Genet. 51(3):343-352(2010)
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