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XPA Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - XPA Antibody (C-term) AP13836B
    Western blot analysis of XPA (arrow) using rabbit polyclonal XPA Antibody (C-term) (Cat. #AP13836b). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the XPA gene.
    detail
  • WB - XPA Antibody (C-term) AP13836B
    XPA Antibody (C-term) (Cat. #AP13836b) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the XPA antibody detected the XPA protein (arrow).
    detail
  • WB - XPA Antibody (C-term) AP13836B
    XPA Antibody (C-term) (Cat. #AP13836b) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the XPA antibody detected the XPA protein (arrow).
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P23025
Other Accession NP_000371.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 31368 Da
Antigen Region 185-213 aa
Additional Information
Gene ID 7507
Other Names DNA repair protein complementing XP-A cells, Xeroderma pigmentosum group A-complementing protein, XPA, XPAC
Target/Specificity This XPA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 185-213 amino acids from the C-terminal region of human XPA.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsXPA Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name XPA
Synonyms XPAC
Function Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.
Cellular Location Nucleus
Tissue Location Expressed in various cell lines and in skin fibroblasts.
Citations (0)
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Background

This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq].

References

Palli, D., et al. Mutagenesis 25(6):569-575(2010)
Fan, W., et al. Mol. Cell 39(2):247-258(2010)
Ho-Pun-Cheung, A., et al. Pharmacogenomics J. (2010) In press :
Hsieh, Y.Y., et al. Anticancer Res. 30(6):2203-2208(2010)
Jelonek, K., et al. J. Appl. Genet. 51(3):343-352(2010)

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$ 182.50
$ 70.00
Cat# AP13836B
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