|Application ||WB, IHC-P, E|
|Other Accession||Q29013, Q00196, NP_002689.1|
|Calculated MW||51209 Da|
|Antigen Region||10-39 aa|
|Other Names||POU domain, class 2, transcription factor 2, Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2, Octamer-binding protein 2, Oct-2, Octamer-binding transcription factor 2, OTF-2, POU2F2, OCT2, OTF2|
|Target/Specificity||This POU2F2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-39 amino acids from the N-terminal region of human POU2F2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||POU2F2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter.|
|Cellular Location||Cytoplasm. Nucleus.|
|Tissue Location||Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line MOLT-4, but not in the T-cell line BW5147|
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Provided below are standard protocols that you may find useful for product applications.
POU2F2 is a transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter.
Galetti, M., et al. Biochem. Pharmacol. 80(2):179-187(2010)
Bailey, S.D., et al. Diabetes Care (2010) In press :
Advani, A.S., et al. Leuk. Lymphoma 51(4):606-612(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Filipski, K.K., et al. Clin. Pharmacol. Ther. 86(4):396-402(2009)
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