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CENPA Antibody (Center)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP13843c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP13843c-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
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CENPA Antibody (Center) - Product info | |
| Application | WB
|
| Primary Accession | P49450 |
| Other Accession | Q8R565, P49449, NP_001800.1, NP_001035891.1 |
| Reactivity | Human |
| Predicted | Bovine, Hamster |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 15991 Da |
CENPA Antibody (Center) - Additional info | |
| Gene ID 1058 | |
| Other Names CENPA; Histone H3-like centromeric protein A; Centromere autoantigen A; Centromere protein A | |
| Target/Specificity This CENPA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-110 amino acids from the Central region of human CENPA. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions CENPA Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
CENPA Antibody (Center) - Protein Information | |
| Name CENPA | |
| Function Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro) | |
| Cellular Location Nucleus. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres. Occupies a compact domain at the inner kinetochore plate stretching across 2 thirds of the length of the constriction but encompassing only one third of the constriction width and height | |
CENPA Antibody (Center) - Related products
AP13843c: CENPA Antibody (Center)
RI11005: CENPA predesign siRNA
DC00415: Human CENPA cDNA Clone
LY12373a: CENPA Over-expression Lysate
CENPA Antibody (Center) - Application data
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CENPA Antibody (Center) (Cat. #AP13843c) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the CENPA antibody detected the CENPA protein (arrow).
CENPA Antibody (Center) - Research Areas
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BACKGROUND
Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq].
REFERENCES
Sekulic, N., et al. Nature 467(7313):347-351(2010) Carroll, C.W., et al. J. Cell Biol. 189(7):1143-1155(2010) Maehara, K., et al. Mol. Cell. Biol. 30(9):2090-2104(2010) Buscaino, A., et al. Curr. Opin. Genet. Dev. 20(2):118-126(2010) Pironon, N., et al. BMC Genomics 11, 195 (2010) :
