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RAB6B Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NRW1 |
| Other Accession | P61294, A6QR46, NP_057661.3 |
| Reactivity | Human |
| Predicted | Bovine, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 23462 Da |
| Antigen Region | 167-195 aa |
| Gene ID | 51560 |
|---|---|
| Other Names | Ras-related protein Rab-6B, RAB6B |
| Target/Specificity | This RAB6B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 167-195 amino acids from the C-terminal region of human RAB6B. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RAB6B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RAB6B (HGNC:14902) |
|---|---|
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (Probable). Recruits VPS13B to the Golgi membrane (PubMed:25492866). Regulates the compacted morphology of the Golgi (PubMed:26209634). Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (PubMed:17707369). Plays a role in neuron projection development (PubMed:25492866). |
| Cellular Location | Golgi apparatus membrane; Lipid-anchor. Endoplasmic reticulum-Golgi intermediate compartment Cytoplasmic vesicle. Note=Colocalizes with BICD1 at vesicular structures that align along microtubules |
| Tissue Location | Predominantly expressed in brain. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
RAB6B seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells.
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Wanschers, B., et al. Cell Motil. Cytoskeleton 65(3):183-196(2008)
Wanschers, B.F., et al. Exp. Cell Res. 313(16):3408-3420(2007)
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
Garcia-Saez, I., et al. Acta Crystallogr. D Biol. Crystallogr. 62 (PT 7), 725-733 (2006) :
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