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SMC1B Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SMC1B Antibody (Center) AP13852C
    SMC1B Antibody (Center) (Cat. #AP13852c) western blot analysis in human normal Uterus tissue lysates (35ug/lane).This demonstrates the SMC1B antibody detected the SMC1B protein (arrow).
  • IHC-P - SMC1B Antibody (Center) AP13852C
    SMC1B Antibody (Center) (Cat. #AP13852c)immunohistochemistry analysis in formalin fixed and paraffin embedded human colon tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SMC1B Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8NDV3
Other Accession NP_683515.3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 143908 Da
Antigen Region 737-765 aa
Additional Information
Gene ID 27127
Other Names Structural maintenance of chromosomes protein 1B, SMC protein 1B, SMC-1-beta, SMC-1B, SMC1B, SMC1L2
Target/Specificity This SMC1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 737-765 amino acids from the Central region of human SMC1B.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSMC1B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SMC1B
Synonyms SMC1L2
Function Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity).
Cellular Location Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. In prophase I stage of meiosis, localizes along the AE of synaptonemal complexes. In late-pachytene-diplotene, the bulk of protein dissociates from the chromosome arms probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. Remains chromatin associated at the centromeres up to metaphase II. At anaphase II, dissociates from centromeres, allowing chromosomes segregation (By similarity).
Research Areas
Citations (0)

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SMC1L2 belongs to a family of proteins required for chromatid cohesion and DNA recombination during meiosis and mitosis (3:Revenkova et al., 2001 [PubMed 11564881]).


Cobbe, N., et al. Mol. Biol. Evol. 21(2):332-347(2004) Revenkova, E., et al. Mol. Cell. Biol. 21(20):6984-6998(2001) Harrington, J.J., et al. Nat. Biotechnol. 19(5):440-445(2001)

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$ 295.00
$ 99.00
Cat# AP13852C
(40 western blots)
Availability: In Stock
Bulk Size
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