|Application ||WB, E|
|Calculated MW||98314 Da|
|Antigen Region||437-466 aa|
|Other Names||Proto-oncogene vav, VAV1, VAV|
|Target/Specificity||This VAV1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 437-466 amino acids from the Central region of human VAV1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||VAV1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.|
|Tissue Location||Widely expressed in hematopoietic cells but not in other cell types|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Hollmann, A., et al. Hematol Oncol 28(3):142-150(2010)
Barda-Saad, M., et al. EMBO J. 29(14):2315-2328(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Kim, H.S., et al. Immunity 32(2):175-186(2010)
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