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VAV1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - VAV1 Antibody (Center) AP13853c
    VAV1 Antibody (Center) (Cat. #AP13853c) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the VAV1 antibody detected the VAV1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P15498
Other Accession NP_005419.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 98314 Da
Antigen Region 437-466 aa
Additional Information
Gene ID 7409
Other Names Proto-oncogene vav, VAV1, VAV
Target/Specificity This VAV1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 437-466 amino acids from the Central region of human VAV1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsVAV1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VAV1
Synonyms VAV
Function Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.
Tissue Location Widely expressed in hematopoietic cells but not in other cell types
Research Areas
Citations (0)

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The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Hollmann, A., et al. Hematol Oncol 28(3):142-150(2010)
Barda-Saad, M., et al. EMBO J. 29(14):2315-2328(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Kim, H.S., et al. Immunity 32(2):175-186(2010)

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$ 295.00
$ 99.00
Cat# AP13853c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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